Seppänen J, Sulkava T, Vaalasti T, Korhonen H, Räisänen S, Ylitalo P
Scand J Infect Dis. 1983;15(2):201-6. doi: 10.3109/inf.1983.15.issue-2.13.
A new antimicrobial drug combination of trimethoprim and methenamine hippurate (TMP + MH) at 2 different dosages (100 + 500 mg and 200 + 1000 mg b.i.d.) was compared by a random double-blind technique with plain TMP (200 mg b.i.d.) and TMP-sulfamethoxazole combination (160 mg + 800 mg b.i.d.). Each of the 4 test groups of 40-47 patients with acute UTI was treated for 2 weeks. The successful response in the test groups varied from 91 to 98% and no statistical difference could be found between the groups. The side-effects were least common in the group treated with the lower dose of TMP-MH combination.
采用随机双盲技术，将两种不同剂量（100 + 500毫克和200 + 1000毫克，每日两次）的新型抗菌药物组合甲氧苄啶和马尿酸乌洛托品（TMP + MH）与普通甲氧苄啶（200毫克，每日两次）以及甲氧苄啶-磺胺甲恶唑组合（160毫克 + 800毫克，每日两次）进行比较。4个试验组，每组40 - 47例急性尿路感染患者，均接受为期2周的治疗。各试验组的有效率在91%至98%之间，组间未发现统计学差异。低剂量TMP - MH组合治疗组的副作用最少见。
