Phares C K, Carroll R M
J Parasitol. 1978 Jun;64(3):401-5.
The effects of bovine growth hormone and the growth factor produced by plerocercoid larvae of the tapeworm, Spirometra mansonoides, on body growth and lipid composition in diabetic-hypophysectomized rats were compared. The diabetic-hypophysectomized control rats gradually lost weight throughout the experiment but both growth hormone and plerocercoids stimulated marked weight gains. Growth hormone treatment resulted in a loss of depot fat from the epididymal fat pads and caused a reduction of liver and serum cholesterol concentrations but had no effect on triglyceride concentrations of either liver or serum. However, plerocercoid infection resulted in increased weights of the epididymal fat pads and increased liver and serum triglyceride concentrations. Serum cholesterol was slightly increased but liver cholesterol was decreased in the plerocercoid-infected rats. Therefore, in the absence of pituitary hormones and insulin, these growth factors had similar effects on body growth but distinctly different effects on lipid metabolism.
比较了牛生长激素和曼氏迭宫绦虫裂头蚴幼虫产生的生长因子对糖尿病性垂体切除大鼠身体生长和脂质组成的影响。在整个实验过程中，糖尿病性垂体切除的对照大鼠体重逐渐减轻，但生长激素和裂头蚴均刺激体重显著增加。生长激素治疗导致附睾脂肪垫中的储存脂肪减少，并使肝脏和血清胆固醇浓度降低，但对肝脏或血清中的甘油三酯浓度没有影响。然而，裂头蚴感染导致附睾脂肪垫重量增加，肝脏和血清甘油三酯浓度升高。裂头蚴感染的大鼠血清胆固醇略有升高，但肝脏胆固醇降低。因此，在缺乏垂体激素和胰岛素的情况下，这些生长因子对身体生长有相似的影响，但对脂质代谢有明显不同的影响。
