Phares C K, Carroll R M
J Parasitol. 1977 Aug;63(4):690-3.
Plerocercoids of the tapeworm, Spirometra mansonoides, produce a potent growth stimulating substance which is active in several species of mammals. While most of the actions of the plerocercoid growth factor (PGF) are similar to those of growth hormone (GH), lipid metabolism is one area where their actions are not alike. This report demonstrates that plerocercoid infection not only stimulates growth of intact male hamsters but is lipogenic as well. The lipogenic effects of plerocercoid infection were demonstrated by increases in epididymal fat pad weights, serum triglycerides, cholesterol, and total lipid. The livers of the plerocercoid-infected hamsters also had more cholesterol and more lipid phosphorus than controls. Incorporation studies using [2-14C]acetate showed that infected hamsters incorporated significantly higher levels of the radionuclide in their livers and serum after 1 hr than the controls. The lipogenic effect of plerocercoid infection is distinctly unlike the reported lipolytic action of GH and the lack of any stimulation of [2-14C]acetate incorporation into the epididymal fat pads is unlike the reported acute actions of insulin as well.
曼氏迭宫绦虫的裂头蚴会产生一种强效生长刺激物质，该物质在多种哺乳动物中具有活性。虽然裂头蚴生长因子（PGF）的大多数作用与生长激素（GH）相似，但脂质代谢是它们作用不同的一个领域。本报告表明，裂头蚴感染不仅能刺激完整雄性仓鼠的生长，还具有生脂作用。裂头蚴感染的生脂作用通过附睾脂肪垫重量、血清甘油三酯、胆固醇和总脂质的增加得以证明。感染裂头蚴的仓鼠肝脏中的胆固醇和脂质磷也比对照组更多。使用[2-14C]乙酸盐的掺入研究表明，感染仓鼠在1小时后肝脏和血清中掺入的放射性核素水平明显高于对照组。裂头蚴感染的生脂作用与报道的GH的脂解作用明显不同，并且缺乏对[2-14C]乙酸盐掺入附睾脂肪垫的任何刺激也与报道的胰岛素的急性作用不同。
