Verheyen A, Vanparijs O, Borgers M, Thienpont D
J Parasitol. 1978 Jun;64(3):411-25.
The time-related topographical changes in mature cysticerci of Taenia taeniaformis induced after medication of infected mice with 250 ppm of mebendazole are described. The changes included the gradual disappearance of microtriches and progressive degeneration of the tegment resulting in an irregular surface with grooves, holes, and craterlike structures. Host cells adhered to the altered areas and the number of these cells increased when more severe changes became apparent. Finally the necrotized cysticerci, which lost their tegument completely, were almost entirely covered with adhesive host cells. A difference in the time sequence of the reported changes occurred between the scolex, the pseudoproglottids, and the bladder. This difference in susceptibility towards the drug between the three parts of the parasite in relation to the morphology of their microtrichous covering is discussed.
描述了用250ppm甲苯咪唑对感染小鼠进行药物治疗后，诱导出的微小膜壳绦虫成熟囊尾蚴的时间相关形态学变化。这些变化包括微毛逐渐消失，皮层进行性退变，导致表面不规则，出现沟、孔和火山口样结构。宿主细胞附着于改变的区域，当更严重的变化出现时，这些细胞的数量增加。最后，完全失去皮层的坏死囊尾蚴几乎完全被粘附的宿主细胞覆盖。在所报道的变化的时间顺序上，头节、假节片和囊泡之间存在差异。讨论了寄生虫这三个部分对药物敏感性的差异与其微毛覆盖形态的关系。
