McLean J R, Gluckman M I
Arzneimittelforschung. 1983;33(4A):627-31.
N-(2,6-Dichloro-m-tolyl)anthranilic acid, sodium salt (meclofenamate sodium, Meclomen), the sodium salt of meclofenamic acid, has anti-inflammatory activity both in animal models and in clinical use. This activity is believed to be due in large part to the ability of the drug to inhibit the synthesis of prostaglandins by inhibiting arachidonic acid cyclo-oxygenase. Further, there is evidence that meclofenamic acid directly antagonizes the actions of prostaglandins at receptor sites. In addition, meclofenamic acid may also inhibit arachidonic acid lipoxygenase, resulting in decreased synthesis of leukotrienes, known mediators involved in the inflammatory process.
N-（2,6-二氯间甲苯基）邻氨基苯甲酸的钠盐（甲氯芬那酸钠，甲氯灭酸），具有抗炎活性，在动物模型和临床应用中均有体现。人们认为这种活性很大程度上归因于该药物通过抑制花生四烯酸环氧化酶来抑制前列腺素合成的能力。此外，有证据表明甲氯芬那酸可在受体部位直接拮抗前列腺素的作用。另外，甲氯芬那酸还可能抑制花生四烯酸脂氧合酶，从而减少白三烯的合成，白三烯是炎症过程中已知的介质。
