Stadler I, Kapui Z, Ambrus J L
Department of Internal Medicine, State University of NY at Buffalo, USA.
J Med. 1994;25(6):371-82.
Meclofenamic acid sodium (Meclomen) was found to inhibit both the cyclooxygenase and the lipoxygenase pathways of arachidonic acid metabolism. It inhibited both 5-lipoxygenase and 15-lipoxygenase activities. Meclomen was also shown to interfere with leukotriene receptors or possibly post-receptor mechanisms. In isolated lung parenchyma strip preparations Meclomen inhibited leukotriene C4 and D4 induced contractions, but had no effect on histamine induced contractions. Ibuprofen, naproxen and indomethacin had no effect on lipoxygenases or on leukotriene receptors but were powerful inhibitors of cyclooxygenases.
甲氯芬那酸钠（甲氯灭酸）被发现可抑制花生四烯酸代谢的环氧化酶和脂氧化酶途径。它同时抑制5-脂氧化酶和15-脂氧化酶的活性。甲氯灭酸还显示出可干扰白三烯受体或可能干扰受体后机制。在离体肺实质条制备中，甲氯灭酸抑制白三烯C4和D4诱导的收缩，但对组胺诱导的收缩没有影响。布洛芬、萘普生和吲哚美辛对脂氧化酶或白三烯受体没有影响，但却是环氧化酶的强效抑制剂。
