Lappin T R, Rich I, Goldwasser E
Exp Hematol. 1983 Aug;11(7):661-6.
The effects of pure and crude human urinary erythropoietin, crude sheep plasma erythropoietin and other growth factors on the incorporation of labeled thymidine were studied using spleen cells from mice previously treated with phenylhydrazine hydrochloride. Erythropoietin at 400 mU/ml caused a 40-80 fold increase in the incorporation of the labeled nucleoside. The slope of the dose-response curve found for pure erythropoietin was not significantly different from that found for a crude urinary erythropoietin preparation or for crude sheep plasma erythropoietin. Colony-stimulating factor, interleukin 2, interleukin 3 and the lectin, concanavalin A were also stimulatory but at concentrations from one hundred to one million times higher than that found for erythropoietin.
使用先前用盐酸苯肼处理过的小鼠脾脏细胞，研究了纯的和粗制的人尿促红细胞生成素、粗制的绵羊血浆促红细胞生成素以及其他生长因子对标记胸腺嘧啶核苷掺入的影响。400 mU/ml的促红细胞生成素使标记核苷的掺入增加了40至80倍。纯促红细胞生成素的剂量反应曲线斜率与粗制尿促红细胞生成素制剂或粗制绵羊血浆促红细胞生成素的斜率无显著差异。集落刺激因子、白细胞介素2、白细胞介素3和凝集素刀豆球蛋白A也具有刺激作用，但浓度比促红细胞生成素高100至100万倍。
