Botzenhardt U, Siegmund J, Siegmund V, Müller J
Immunobiology. 1983 Jul;165(1):36-45. doi: 10.1016/S0171-2985(83)80045-X.
By means of the Simonson GVH-assay and the popliteal lymph node (PLN) assay, the T-cell reactivity of NZB mice against H-2 identical allogenic cells was investigated in vivo and compared to that of normal mice. None of the normal mice did react, but a highly significant NZB response could be demonstrated, which did not depend on differences in Mls antigens. These in vivo results extend previous findings of a T-cell hyperreactivity of NZB mice in primary in vitro reactions. They favour the possibility that the T-cell hyperreactivity might be relevant in vivo in facilitating autoimmune responses.
通过西蒙森移植物抗宿主（GVH）试验和腘窝淋巴结（PLN）试验，在体内研究了NZB小鼠对H-2相同同种异体细胞的T细胞反应性，并与正常小鼠进行了比较。正常小鼠均无反应，但可证明NZB小鼠有高度显著的反应，且该反应不依赖于Mls抗原的差异。这些体内实验结果扩展了之前关于NZB小鼠在原发性体外反应中T细胞反应性过高的发现。它们支持T细胞反应性过高可能在体内促进自身免疫反应中起作用的可能性。
