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NZB小鼠体外针对Mls抗原的原发性细胞毒性T细胞反应。

Primary cytotoxic T-cell response in vitro against Mls antigens in NZB-mice.

作者信息

Botzenhardt U, Müller-Quernheim J

机构信息

I. Medizinische Klinik, Johannes Gutenberg Universität, Mainz, FRG.

出版信息

Clin Exp Immunol. 1987 Sep;69(3):647-51.

PMID:2959414
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542367/
Abstract

NZB-mice have a T cell hyperreactivity based on a primary response to minor histocompatibility antigens (MIH) on target cells identical to NZB on the H-2 complex (MHC). We tested the idea that a single MIH difference on MHC identical target cells is sufficient to elicit such a primary response in vitro. Cytotoxic T lymphocyte (CTL) response and activated T-helper cell (THC) frequencies were evaluated. NZB x CBA/J (Mls a/d) and NZB x CBA/Ca (Mls a/b) hybrids, which differ only at the M-locus, were raised. A primary cytotoxic response in the direction Mls b anti Mls d, but not vice versa was observed in vitro. In the assay used no unusual THC frequencies against Mls d could be demonstrated. The results favour cellular hyperreactivity in NZB which can be elicited by a single MIH antigen alone.

摘要

NZB小鼠对与H-2复合体（主要组织相容性复合体，MHC）上的NZB相同的靶细胞上的次要组织相容性抗原（MIH）存在基于初次反应的T细胞反应过度。我们测试了这样一种观点，即在MHC相同的靶细胞上单个MIH差异足以在体外引发这种初次反应。评估了细胞毒性T淋巴细胞（CTL）反应和活化的T辅助细胞（THC）频率。培育了仅在M位点不同的NZB×CBA/J（Mls a/d）和NZB×CBA/Ca（Mls a/b）杂种。在体外观察到了Mls b抗Mls d方向的初次细胞毒性反应，但反之则未观察到。在所使用的检测方法中，未证明对Mls d存在异常的THC频率。结果支持NZB中细胞反应过度，这可由单一的MIH抗原单独引发。

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本文引用的文献

1
Enumeration of alloreactive helper T lymphocytes which cooperate with cytolytic T lymphocytes.与细胞溶解性T淋巴细胞协同作用的同种异体反应性辅助性T淋巴细胞的计数。
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Maternally transmitted target antigen for unrestricted killing by NZB T lymphocytes.可被NZB T淋巴细胞无限制杀伤的母系传播靶抗原。
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On the T cell hyperreactivity of NZB mice against H-2-identical cells. Evidence for primary response characteristics and an increased helper potential.关于新西兰黑鼠（NZB）对H-2相同细胞的T细胞高反应性。初次反应特征及辅助潜能增加的证据。
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Qed-1--a target for unrestricted killing by T cells.Qed-1——T细胞无限制杀伤的一个靶点。
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Nature. 1983;306(5938):80-2. doi: 10.1038/306080a0.
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T-T cell interactions during in vitro cytotoxic T lymphocyte responses. V. Precursor frequencies and specificity of alloreactive helper T cells.体外细胞毒性T淋巴细胞反应期间的T - T细胞相互作用。V. 同种异体反应性辅助性T细胞的前体细胞频率和特异性。
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The immunobiology of the T cell response to Mls-locus-disparate stimulator cells. I. Unidirectionality, new strain combinations, and the role of Ia antigens.T细胞对Mls位点不同的刺激细胞反应的免疫生物学。I. 单向性、新的品系组合以及Ia抗原的作用。
J Immunol. 1985 Apr;134(4):2057-63.
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Primary in vitro cell-mediated lympholysis reaction of NZB mice against unmodified targets syngeneic at the major histocompatibility complex.新西兰黑小鼠针对主要组织相容性复合体同基因未修饰靶标的原发性体外细胞介导的淋巴细胞溶解反应。
J Exp Med. 1978 May 1;147(5):1435-48. doi: 10.1084/jem.147.5.1435.
9
Primary in vitro cytotoxic response of NZB spleen cells to Qa-1b-associated antigenic determinants.NZB脾细胞对Qa-1b相关抗原决定簇的原发性体外细胞毒性反应。
J Exp Med. 1979 Dec 1;150(6):1555-60. doi: 10.1084/jem.150.6.1555.
10
The Mls system.Mls系统。
Transplant Proc. 1976 Sep;8(3):339-42.

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