通过正电子断层扫描对人脑多巴胺受体进行成像。
Imaging dopamine receptors in the human brain by positron tomography.
作者信息
Wagner H N, Burns H D, Dannals R F, Wong D F, Langstrom B, Duelfer T, Frost J J, Ravert H T, Links J M, Rosenbloom S B, Lukas S E, Kramer A V, Kuhar M J
出版信息
Science. 1983 Sep 23;221(4617):1264-6. doi: 10.1126/science.6604315.
PMID:6604315
Abstract
Neurotransmitter receptors may be involved in a number of neuropsychiatric disease states. The ligand 3-N-[11C]methylspiperone, which preferentially binds to dopamine receptors in vivo, was used to image the receptors by positron emission tomography scanning in baboons and in humans. This technique holds promise for noninvasive clinical studies of dopamine receptors in humans.
摘要
神经递质受体可能参与多种神经精神疾病状态。配体3-N-[¹¹C]甲基螺哌隆在体内优先与多巴胺受体结合，通过正电子发射断层扫描用于在狒狒和人类中对这些受体进行成像。这项技术有望用于人类多巴胺受体的无创临床研究。
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