Neumüller J, Senautka G, Dunky A, Neumann H, Mayer F, Much T, Eberl R, Partsch G
Wien Klin Wochenschr. 1983 Jun 10;95(12):416-22.
The function of cellular immunity factors (lymphocyte transformation and phagocytosis by polymorphonuclear leucocytes [PMN] and monocytes in connection with the concentration of intracellular ATP) and humoral immunity factors (serum concentration of immunoglobulin and complement factors C'3 and C'4) was investigated in 16 controls, 21 patients with psoriatic arthritis and 19 with psoriasis vulgaris. The results were compared with the clinical and anamnestic data of the patients. PMN phagocytosis of zymosan opsonized with rabbit standard serum was decreased in psoriasis vulgaris in comparison with the controls. Also, monocyte phagocytosis of non-opsonized zymosan was decreased in psoriatic arthritis, as compared with psoriasis vulgaris. Furthermore, in PMNs intracellular ATP was elevated in psoriatic arthritis as compared with the controls, but decreased in comparison with patients with psoriasis vulgaris. The intracellular ATP in monocytes was decreased in psoriasis vulgaris as compared with the controls. Humoral immunological findings: serum IgG concentration was higher in psoriatic arthritis than in controls and in psoriasis vulgaris. Elevated C'3 and decreased C'4 serum concentrations in psoriatic arthritis indicate an activation of the complement system.
在16名对照组、21名银屑病关节炎患者和19名寻常型银屑病患者中，研究了细胞免疫因子（淋巴细胞转化以及多形核白细胞[PMN]和单核细胞的吞噬作用与细胞内ATP浓度的关系）和体液免疫因子（免疫球蛋白的血清浓度以及补体因子C'3和C'4）的功能。将结果与患者的临床和既往病史数据进行了比较。与对照组相比，寻常型银屑病患者中用兔标准血清调理的酵母聚糖的PMN吞噬作用降低。此外，与寻常型银屑病相比，银屑病关节炎患者中非调理酵母聚糖的单核细胞吞噬作用降低。此外，与对照组相比，银屑病关节炎患者PMN中的细胞内ATP升高，但与寻常型银屑病患者相比降低。与对照组相比，寻常型银屑病患者单核细胞中的细胞内ATP降低。体液免疫结果：银屑病关节炎患者血清IgG浓度高于对照组和寻常型银屑病患者。银屑病关节炎患者血清C'3升高和C'4降低表明补体系统被激活。
