银屑病或银屑病关节炎患者中HLA抗原的频率。
Frequency of HLA antigens in patients with psoriasis or psoriatic arthritis.
作者信息
McKendry R J, Sengar D P, DesGroseilliers J P, Dunne J V
出版信息
Can Med Assoc J. 1984 Feb 15;130(4):411-5.
A study of 138 patients with psoriasis--74 with psoriasis alone and 64 with psoriatic arthritis--revealed a significantly increased frequency of the HLA antigens A1, A28, B13, DR7 and MT3 in those with psoriasis alone and of Bw39 in those with psoriatic arthritis. The frequency of B17 was higher in both patient groups than in a control group of healthy individuals. The frequency of DRw6 was slightly higher in the patients with psoriasis alone (17.8%) than in the controls (4.7%), and that of DR7 was higher in the patients with psoriatic arthritis (52.9%) than in the controls (32.6%). Elevated levels of serum IgG and IgA along with positive results of tests for antinuclear antibody or rheumatoid factor or both were present in less than a tenth of the patients with psoriatic rash alone and in up to a third of those with psoriatic arthritis. Psoriatic arthritis was found to be less likely to develop in patients with purely guttate psoriasis than in those with other types of psoriasis. Clinical subtypes of psoriatic rash or psoriatic arthritis were not associated with the presence of particular HLA antigens.
一项针对138例银屑病患者的研究——其中74例为单纯银屑病患者，64例为银屑病关节炎患者——发现，单纯银屑病患者中HLA抗原A1、A28、B13、DR7和MT3的出现频率显著增加，而银屑病关节炎患者中Bw39的出现频率显著增加。两个患者组中B17的出现频率均高于健康个体组成的对照组。单纯银屑病患者中DRw6的出现频率（17.8%）略高于对照组（4.7%），银屑病关节炎患者中DR7的出现频率（52.9%）高于对照组（32.6%）。单纯有银屑病皮疹的患者中，不到十分之一的患者血清IgG和IgA水平升高，同时抗核抗体或类风湿因子检测呈阳性，或两者均呈阳性；而银屑病关节炎患者中，这一比例高达三分之一。研究发现，与其他类型银屑病患者相比，单纯点滴状银屑病患者患银屑病关节炎的可能性较小。银屑病皮疹或银屑病关节炎的临床亚型与特定HLA抗原的存在无关。
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