重症肌无力中周围T淋巴细胞对乙酰胆碱受体的特异性参与。
Specific involvement of peripheral T lymphocytes against acetylcholine receptors in myasthenia gravis.
作者信息
Conti-Tronconi B M, Scotti A, Sghirlanzoni A, Clementi F
出版信息
J Neurol Neurosurg Psychiatry. 1983 Sep;46(9):832-6. doi: 10.1136/jnnp.46.9.832.
Abstract
A specific sensitisation of blood T lymphocytes against the nicotinic acetylcholine receptor has been demonstrated in myasthenic patients. After thymectomy the T lymphocytes response was quickly decreased and in most patients it reached normal values. The T response remained at low or normal levels for at least two years. In patients who had undergone thymectomy three or more years before, a T lymphocyte response against acetylcholine receptors was frequently detected.
摘要
重症肌无力患者体内已证实存在血液中T淋巴细胞对烟碱型乙酰胆碱受体的特异性致敏现象。胸腺切除术后，T淋巴细胞反应迅速降低，大多数患者的反应达到正常水平。T反应至少两年维持在低水平或正常水平。在胸腺切除三年或更长时间之前的患者中，经常检测到T淋巴细胞对乙酰胆碱受体的反应。
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2
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