Alarcón G S, Koopman W J, Acton R T, Barger B O
J Rheumatol. 1983 Aug;10(4):579-83.
DR antigen distribution was studied in 85 Blacks with either classical or definite rheumatoid arthritis (RA). Sixty-three were seropositive and 22 were seronegative by latex fixation titer. The frequency of DR4 was 7.41% in our control Black population (n = 162), 22.22% in the seropositive (0.01 greater than p greater than 0.001; RR 3.57) and 22.72% in the seronegative RA (0.01 greater than p greater than 0.001; RR 3.67). Our data confirm the association of DR4 with seropositive RA in Blacks, and suggest a similar association of DR4 with seronegative RA. It also suggests that DR4 may be a risk factor for more aggressive disease in Blacks with seropositive RA.
对85例患有典型或确诊类风湿性关节炎（RA）的黑人患者进行了DR抗原分布研究。通过乳胶凝集试验效价检测，其中63例为血清阳性，22例为血清阴性。在我们的黑人对照组人群（n = 162）中，DR4的频率为7.41%，血清阳性患者中为22.22%（0.01 > p > 0.001；相对危险度RR为3.57），血清阴性RA患者中为22.72%（0.01 > p > 0.001；RR为3.67）。我们的数据证实了DR4与黑人血清阳性RA之间的关联，并提示DR4与血清阴性RA之间存在类似关联。这也表明DR4可能是黑人血清阳性RA患者病情更具侵袭性的一个危险因素。
