Matsuo T, Murase K, Wago M, Matsuo S, Ikeda T, Yamaguchi T
Gan No Rinsho. 1983 Aug;29(9):1035-9.
A 65-year-old man with acute lymphoblastic leukemia of B-cell origin is described. The patient had many distinctive features including a very high blast cell count, hepatomegaly, hemorrhagic diathesis and a fulminant clinical course. Immunological studies showed the blast cells to have surface characteristics of B-lymphoid cells (IgG kappa). These cells had moderate amounts of deeply basophilic cytoplasm without granules. Most cells contained empty cytoplasmic vacuoles (L3 according to the FBA classification). Autopsy confirmed wide-spread leukemia involving the bone marrow, spleen, liver, kidneys, lungs, adrenals, thyroid gland, stomach, rectum, root ganglia and lymph nodes. This case is an example of acute lymphoblastic leukemia with Burkitt's tumor cells (L3).
本文描述了一名65岁起源于B细胞的急性淋巴细胞白血病男性患者。该患者有许多独特特征，包括原始细胞计数非常高、肝肿大、出血素质以及暴发性临床病程。免疫学研究显示原始细胞具有B淋巴细胞的表面特征（IgG κ）。这些细胞有中等量的深嗜碱性细胞质且无颗粒。大多数细胞含有空的细胞质空泡（根据FBA分类为L3）。尸检证实白血病广泛累及骨髓、脾脏、肝脏、肾脏、肺、肾上腺、甲状腺、胃、直肠、神经根神经节和淋巴结。该病例是一例伴有伯基特肿瘤细胞（L3）的急性淋巴细胞白血病。
