Preud'homme J L, Brouet J C, Danon F, Flandrin G, Schaison G
J Natl Cancer Inst. 1981 Feb;66(2):261-4.
Blast cells from 24 patients with acute lymphoblastic leukemia of Burkitt's cell type were studied for lymphocyte surface markers. The leukemia cells were of B-cell origin in 23 cases and showed a non-B, non-T phenotype in 1 case. Surface immunoglobulins on blast cells were monoclonal, with a striking predominance of cases with light chains of lambda type. They consisted most often of high-density IgM usually without associated IgD. However, 3 patients had cells with surface IgG and 1 had surface IgA. The blast cells lacked detectable IgG Fc receptors in more than half the patients. Serum immunoglobulins were studied in 15 cases: A monoclonal IgM was found in 5 patients (whose blast cells had surface IgM) and a Bence Jones protein was found in 2 others, both of whom had blasts with surface IgG lambda.
对24例伯基特细胞型急性淋巴细胞白血病患者的原始细胞进行了淋巴细胞表面标志物研究。23例患者的白血病细胞起源于B细胞，1例表现为非B、非T表型。原始细胞表面免疫球蛋白为单克隆性，以λ型轻链为主的病例显著居多。它们大多由高密度IgM组成，通常无相关IgD。然而，3例患者的细胞有表面IgG，1例有表面IgA。超过半数患者的原始细胞缺乏可检测到的IgG Fc受体。对15例患者的血清免疫球蛋白进行了研究：5例患者（其原始细胞有表面IgM）发现单克隆IgM，另外2例发现本周氏蛋白，这2例患者的原始细胞均有表面IgGλ。
