Fisher L A, Kikkawa D O, Rivier J E, Amara S G, Evans R M, Rosenfeld M G, Vale W W, Brown M R
Nature. 1983;305(5934):534-6. doi: 10.1038/305534a0.
Alternative splicing of RNA transcripts from the calcitonin gene produces mRNAs that encode different polypeptides. While the mRNA encoding calcitonin predominates in thyroidal 'C' cells, calcitonin gene-related peptide (CGRP) mRNA appears to be the major mRNA component in non-thyroid tissue, including brain. The predicted peptide arising from translation of CGRP mRNA has now been identified immunocytochemically throughout the central and peripheral nervous systems. CGRP, a 37-residue peptide, is distributed in brain pathways subserving sensory, motor and autonomic functions. We report here that CGRP acts in the central nervous system to stimulate selectively noradrenergic sympathetic outflow.
降钙素基因的RNA转录本的可变剪接产生编码不同多肽的mRNA。虽然编码降钙素的mRNA在甲状腺“C”细胞中占主导地位，但降钙素基因相关肽（CGRP）mRNA似乎是非甲状腺组织（包括脑）中的主要mRNA成分。现已通过免疫细胞化学方法在整个中枢和外周神经系统中鉴定出由CGRP mRNA翻译产生的预测肽。CGRP是一种由37个氨基酸残基组成的肽，分布于脑内负责感觉、运动和自主功能的通路中。我们在此报告，CGRP在中枢神经系统中起作用，选择性地刺激去甲肾上腺素能交感神经输出。
