血管紧张素原与抗胰蛋白酶-抗凝血酶-卵清蛋白家族相关。
Angiotensinogen is related to the antitrypsin-antithrombin-ovalbumin family.
作者信息
Doolittle R F
出版信息
Science. 1983 Oct 28;222(4622):417-9. doi: 10.1126/science.6604942.
PMID:6604942
Abstract
The recently reported amino acid sequence of rat angiotensinogen was subjected to a computer-assisted search for homology with known sequences stored in a data bank and found to be significantly related to that of plasma alpha 1-antitrypsin, itself a member of a family that includes antithrombin III and ovalbumin. An alignment of the four sequences shows indisputably the common ancestry of all four proteins.
摘要
最近报道的大鼠血管紧张素原氨基酸序列，经过计算机辅助搜索，与数据库中存储的已知序列进行同源性比对，结果发现它与血浆α1-抗胰蛋白酶的序列有显著相关性，而α1-抗胰蛋白酶本身就是一个家族的成员，该家族还包括抗凝血酶III和卵清蛋白。这四个序列的比对无可争议地显示了所有这四种蛋白质有着共同的祖先。
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