Kolb E
Z Gesamte Inn Med. 1983 Jul 1;38(13):337-44.
In the mucous membrane of the gastro-intestinal canal large quantities of T- and B-lymphocytes appear which are in constant renovation. The lymphocytes situated intraepithelially and in the lamina propria have a contact with the antigens touching the mucous membrane or taken into it (alimentary proteins, bacteria, viruses, protozoa), by means of which a more or less important evocation of immune reactions is brought about. IgA-molecules formed by plasma cells of the mucous membrane are given into the lumen and there they bind antigens, by means of which these are prevented from the connection with the epithelial cells. A part of the IgA-molecules is transported into the liver via the blood plasma and the lymph, respectively, where a destruction of the antigen-IgA-complexes takes place. The IgA-molecules are excreted via the bile into the intestine. Under certain conditions an allergy against alimentary proteins (lactoprotein, egg white protein, cereal protein) develops. Lymphocytes carried off from the intestinal canal settle in other tissues and may mediate "immunological experience", which is particularly of importance in the milk secretion.
在胃肠道黏膜中出现大量不断更新的T淋巴细胞和B淋巴细胞。上皮内和固有层中的淋巴细胞与接触或进入黏膜的抗原（食物蛋白、细菌、病毒、原生动物）接触，由此引发或多或少重要的免疫反应。黏膜浆细胞形成的IgA分子被释放到管腔中，在那里它们结合抗原，从而防止这些抗原与上皮细胞结合。一部分IgA分子分别通过血浆和淋巴转运到肝脏，在那里抗原-IgA复合物被破坏。IgA分子通过胆汁排泄到肠道。在某些情况下，会发生对食物蛋白（乳蛋白、蛋清蛋白、谷物蛋白）的过敏反应。从肠道带走的淋巴细胞定居在其他组织中，并可能介导“免疫经验”，这在乳汁分泌中尤为重要。
