Schreiber S, Raedler A
Medizinische Kern- und Poliklinik, Universitäts-Krankenhaus Eppendorf, Hamburg.
Immun Infekt. 1993 Apr;21 Suppl 1:31-3.
The intestinal immune system has to protect the mucosa against microbial and toxic agents. This is achieved by elimination of potential antigens, which are inhibited to adhere and to invade the mucosa. Thus, induction of inflammatory processes is prevented. Elimination of antigens is mediated by the secretion and transport of IgA (and especially IgA2) to the lumen of the gut. There, IgA is the most efficient part of the so-called "mucosa block". The composition of mononuclear cells in the lamina propria exhibits the preference of a memory T cell type that is able to provide help for B cells. If IgA-mediated immune response proves not to be sufficient, IgG-mediated inflammatory processes are induced within the mucosa. The role of cytotoxic T cells and, moreover, the biological function of intraepithelial lymphocytes are still controversial.
肠道免疫系统必须保护黏膜免受微生物和有毒物质的侵害。这是通过清除潜在抗原实现的，这些潜在抗原会被抑制黏附并侵入黏膜。因此，可预防炎症过程的诱导。抗原的清除是由IgA（尤其是IgA2）分泌并转运至肠腔介导的。在那里，IgA是所谓“黏膜屏障”中最有效的部分。固有层中单核细胞的组成表现出记忆性T细胞类型的偏好，这种类型能够为B细胞提供帮助。如果IgA介导的免疫反应被证明是不足的，那么黏膜内就会诱导IgG介导的炎症过程。细胞毒性T细胞的作用，以及上皮内淋巴细胞的生物学功能仍存在争议。
