西班牙西北部加利西亚地区Pi、TfC和Gc亚型的分布情况。

Distribution of the Pi, TfC, and Gc subtypes in Galicia (North West Spain).

作者信息

Carracedo A, Concheiro L

出版信息

Z Rechtsmed. 1983;90(2):153-8. doi: 10.1007/BF02092300.

DOI:10.1007/BF02092300

Abstract

Alpha 1-antitrypsin (Pi), Gc, and TfC subtypes were determined by isoelectric focusing in thin layer agarose (AGIF) and polyacrylamide gels (PAGIF) in a total of 480 individuals from Galicia. The following gene frequencies were observed: for Pi:PiM1:0.660; PiM2:0.115; PiM3:0.060; PiS:0.149; PiZ:0.009; PiF:0.005; PiI:0.001; for Gc:Gc1S:0.572; Gc1F:0.120; Gc2:0.308; for TfC: TfC1:0.778; TfC2:0.180; TfC3:0.041; TfC6:0.001. A rare variant TfC6-2 was found and the intrafamilial distribution of the TfC6 allele studied. The use of these systems for forensic purposes and the peculiar distribution of some of their alleles in the Galician population are discussed.

摘要

通过在薄层琼脂糖（AGIF）和聚丙烯酰胺凝胶（PAGIF）中进行等电聚焦，对来自加利西亚的480名个体的α1-抗胰蛋白酶（Pi）、Gc和TfC亚型进行了测定。观察到以下基因频率：对于Pi：PiM1：0.660；PiM2：0.115；PiM3：0.060；PiS：0.149；PiZ：0.009；PiF：0.005；PiI：0.001；对于Gc：Gc1S：0.572；Gc1F：0.120；Gc2：0.308；对于TfC：TfC1：0.778；TfC2：0.180；TfC3：0.041；TfC6：0.001。发现了一种罕见的变体TfC6-2，并研究了TfC6等位基因的家族内分布。讨论了这些系统在法医鉴定中的应用以及它们的一些等位基因在加利西亚人群中的特殊分布情况。