Grisafe J A, Hayton W L
J Pharm Sci. 1978 Jul;67(7):895-9. doi: 10.1002/jps.2600670706.
The intestinal absorption rate of dissolved griseofulvin was determined from: (a) an aqueous phase, (b) an aqueous phase containing a micellar phase composed of taurodeoxycholate, monoolein, and oleic acid, and (c) an aqueous phase containing the micellar phase and emulsified triolein. The triolein digestion mixtures were recirculated through 20-cm segments of in situ rat jejunum. Lipid concentrations were maintained constant by infusing the lipids into the digestion mixture at the same rate as they disappeared. Griseofulvin distribution among the aqueous, micellar, and oil phases was determined by solubility and equilibrium dialysis experiments. Analysis with a linear kinetic model indicated that griseofulvin absorption from the micellar and oil phases was negligible compared to its absorption from the aqueous phase.
(a) 水相；(b) 含有由牛磺脱氧胆酸盐、单油酸甘油酯和油酸组成的胶束相的水相；(c) 含有胶束相和乳化三油酸甘油酯的水相。三油酸甘油酯消化混合物通过原位大鼠空肠的20厘米段进行再循环。通过以脂质消失的相同速率将脂质注入消化混合物来维持脂质浓度恒定。通过溶解度和平衡透析实验测定了灰黄霉素在水相、胶束相和油相之间的分布。线性动力学模型分析表明，与从水相吸收相比，灰黄霉素从胶束相和油相的吸收可忽略不计。
