Antelman S M, DeGiovanni L A, Kocan D, Perel J M, Chiodo L A
Life Sci. 1983 Oct 24;33(17):1727-30. doi: 10.1016/0024-3205(83)90730-0.
Daily treatment for 10 days with either amitriptyline or the tricyclic muscle relaxant, cyclobenzaprine, increased the incidence of head-twitch behavior in response to 5-hydroxytryptophan (5-HTP) when this was examined two days later. Only one day of amitriptyline treatment followed by an 11-day hiatus before administration of 5-HTP also sensitized the head-twitch response whereas similar amitriptyline treatment followed by 5-HTP one hour later failed to do so. These data provide the first evidence for time-dependent sensitization of brain serotonin systems.
在使用阿米替林或三环类肌肉松弛剂环苯扎林进行为期10天的每日治疗后，两天后检测发现，对5-羟色氨酸（5-HTP）产生的头部抽搐行为的发生率增加。仅进行一天的阿米替林治疗，然后在给予5-HTP之前间隔11天，也会使头部抽搐反应敏感化，而类似的阿米替林治疗后1小时给予5-HTP则不会出现这种情况。这些数据为脑血清素系统的时间依赖性敏感化提供了首个证据。
