Csernansky J G, Bellows E P, Barnes D E, Lombrozo L
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305.
Psychopharmacology (Berl). 1990;101(4):519-24. doi: 10.1007/BF02244231.
Recent clinical research suggests that particular patterns of changes in presynaptic dopamine (DA) turnover accompany the therapeutic response to neuroleptics. We sought to determine whether daily versus weekly dosing of haloperidol for 3 weeks produced distinct effects on DA, dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) concentrations in multiple brain areas. Daily dosing favored the development of tolerance to the DA-turnover elevating effects of haloperidol in the striatum and nucleus accumbens. Weekly dosing favored the development of sensitization in the striatum, posterior olfactory tubercle, and ventral tegmental area. These results suggest that dosing schedules may determine, at least in part, the effects of chronic neuroleptic administration on presynaptic DA function.
近期临床研究表明，突触前多巴胺（DA）周转的特定变化模式与抗精神病药物的治疗反应相关。我们试图确定，连续3周每日服用氟哌啶醇与每周服用一次氟哌啶醇，对多个脑区的DA、二羟基苯乙酸（DOPAC）和高香草酸（HVA）浓度是否产生不同影响。每日给药有利于纹状体和伏隔核中对氟哌啶醇DA周转升高作用产生耐受性。每周给药有利于纹状体、后嗅结节和腹侧被盖区产生敏化作用。这些结果表明，给药方案可能至少部分决定了长期服用抗精神病药物对突触前DA功能的影响。
