Johnels B
Pharmacol Biochem Behav. 1982 Aug;17(2):283-9. doi: 10.1016/0091-3057(82)90082-x.
A mechanographic method was used to assess the locomotor performance induced by apomorphine or other dopaminergic drugs in reserpine-treated rats. Reserpine was found to induce locomotor hypokinesia. The hypokinesia was dose-dependently reversed by apomorphine (APO), bromocriptine and pergolide. Locomotion was induced by microinjection of APO into the nucleus accumbens. No locomotor effect was found after injection into corpus striatum. Injection into both nuclei was not superior to accumbens only. Intra-striatal or intraaccumbens injections of trifluoperazine blocked the effect on locomotion by systematic apomorphine. The results confirmed that reserpine-induced locomotor hypokinesia is reversed by dopaminergic stimulation in the nucleus accumbens. There were indications that blockade of striatal or accumbens' dopamine receptors counteracts apomorphine-induced locomotion presumably by interaction with postural motor control. Evidence was found for separate dopaminergic control of locomotion and muscletone. This may be of importance for the development of new antiparkinson drugs.
采用机械记录法评估阿扑吗啡或其他多巴胺能药物对利血平处理大鼠运动能力的影响。发现利血平可诱发运动迟缓。阿扑吗啡（APO）、溴隐亭和培高利特可剂量依赖性地逆转这种运动迟缓。向伏隔核微量注射APO可诱发运动。向纹状体注射后未发现运动效应。向两个核团注射并不比仅向伏隔核注射更有效。纹状体内或伏隔核内注射三氟拉嗪可阻断系统性阿扑吗啡对运动的影响。结果证实，伏隔核中的多巴胺能刺激可逆转利血平诱发的运动迟缓。有迹象表明，阻断纹状体或伏隔核的多巴胺受体会抵消阿扑吗啡诱发的运动，这可能是通过与姿势运动控制相互作用实现的。有证据表明，运动和肌张力受不同的多巴胺能控制。这可能对新型抗帕金森病药物的研发具有重要意义。
