Lee L A, Bias W B, Arnett F C, Huff J C, Norris D A, Harmon C, Provost T T, Weston W L
Ann Intern Med. 1983 Nov;99(5):592-6. doi: 10.7326/0003-4819-99-5-592.
Infants with neonatal lupus erythematosus have congenital heart block, transient cutaneous lesions, or both. Mothers of these infants have SSA/Ro autoantibodies that are passed across the placenta to the fetus and that have been temporarily associated with the syndrome. Six families with neonatal lupus were studied by HLA typing. All seven infants had transient cutaneous lesions, congenital heart block, or both. Five of six mothers were asymptomatic and one had Sjögren's syndrome. Six of seven infants and all six mothers had antibodies to SSA/Ro in their sera. The infants became seronegative by age 8 months. Five mothers were positive for HLA-DR3, five for HLA-MB2, six for HLA-MT2, and six for HLA-B8. No HLA associations were seen in infants. Gene products of the DR or similar regions may be associated with autoantibody production but not with other events in tissue injury.
患有新生儿红斑狼疮的婴儿会出现先天性心脏传导阻滞、短暂性皮肤病变，或两者皆有。这些婴儿的母亲体内有抗SSA/Ro自身抗体，这些抗体可经胎盘传递给胎儿，并与该综合征暂时相关。通过HLA分型对六个患有新生儿狼疮的家庭进行了研究。所有七个婴儿都有短暂性皮肤病变、先天性心脏传导阻滞，或两者皆有。六位母亲中有五位无症状，一位患有干燥综合征。七个婴儿中有六个以及所有六位母亲的血清中都有抗SSA/Ro抗体。这些婴儿在8个月大时血清反应变为阴性。五位母亲的HLA-DR3呈阳性，五位HLA-MB2呈阳性，六位HLA-MT2呈阳性，六位HLA-B8呈阳性。在婴儿中未发现HLA关联。DR或类似区域的基因产物可能与自身抗体的产生有关，但与组织损伤中的其他事件无关。
