单环β-内酰胺类药物SQ 26,917的体外活性及β-内酰胺酶稳定性，与氨曲南及其他药物的比较
In vitro activity and beta-lactamase stability of a monobactam, SQ 26,917, compared with those of aztreonam and other agents.
作者信息
Neu H C, Labthavikul P
出版信息
Antimicrob Agents Chemother. 1983 Aug;24(2):227-32. doi: 10.1128/AAC.24.2.227.
Abstract
SQ 26,917 is a monobactam antibiotic. Its in vitro activity was compared with those of aztreonam, cefotaxime, ceftazidime, and moxalactam. SQ 26,917, which contains a beta-methyl configuration on the beta-lactam ring, was similar in activity to aztreonam with the exception of greater activity against Pseudomonas aeruginosa isolates. SQ 26,917 had no activity against gram-positive isolates or anaerobic bacteria. It was not hydrolyzed by common plasmid and chromosomal beta-lactamases.
摘要
SQ 26,917是一种单环β-内酰胺类抗生素。将其体外活性与氨曲南、头孢噻肟、头孢他啶和莫西沙星的活性进行了比较。SQ 26,917在β-内酰胺环上含有β-甲基构型，其活性与氨曲南相似，但对铜绿假单胞菌分离株的活性更强。SQ 26,917对革兰氏阳性菌分离株或厌氧菌无活性。它不会被常见的质粒和染色体β-内酰胺酶水解。
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