对不同氨基糖苷类和十种β-内酰胺类抗生素敏感性的铜绿假单胞菌分离株的体外比较
In vitro comparison of Pseudomonas aeruginosa isolates with various susceptibilities to aminoglycosides and ten beta-lactam antibiotics.
作者信息
Wu D H, Baltch A L, Smith R P
出版信息
Antimicrob Agents Chemother. 1984 Apr;25(4):488-90. doi: 10.1128/AAC.25.4.488.
Abstract
Susceptibilities of 98 clinical isolates of Pseudomonas aeruginosa, including 33 strains with known mechanisms of amikacin resistance, were tested by the agar dilution method against 10 beta-lactam drugs. Ceftazidime, imipenem, and cefsulodin had the greatest activity, regardless of the aminoglycoside susceptibilities. The strains which were highly resistant to amikacin appeared to be less susceptible to some beta-lactam drugs, especially if their resistance was related to amikacin-inactivating enzymes; statistical significance, however, was observed for aztreonam only.
摘要
采用琼脂稀释法，对98株铜绿假单胞菌临床分离株（包括33株已知阿米卡星耐药机制的菌株）进行了10种β-内酰胺类药物的药敏试验。无论氨基糖苷类药物敏感性如何，头孢他啶、亚胺培南和头孢磺啶的活性最强。对阿米卡星高度耐药的菌株似乎对某些β-内酰胺类药物的敏感性较低，尤其是当它们的耐药性与阿米卡星失活酶有关时；然而，仅对氨曲南观察到统计学意义。
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