Male D, Pryce G, Quartey-Papafio R, Roitt I
Eur J Immunol. 1983 Nov;13(11):942-7. doi: 10.1002/eji.1830131114.
Anti-idiotypic antibodies were raised in rabbits to three monoclonal mouse autoanti-thyroglobulins. Of the idiotypes recognized, one was unique to that monoclonal, while the other two showed evidence of sharing idiotopes with other monoclonal anti-thyroglobulin (TG) idiotypes, the IgM idiotype in particular being found on nearly half of the hybridomas studied. Two of the idiotypes could be detected in the sera of mice with experimental allergic thyroiditis (EAT), but they constituted only a very small percentage of the total anti-TG present. In spite of its low levels in EAT mice the D8 idiotype could be induced by injection of anti-idiotype and TG and in this case it constituted up to 20% of the anti-TG activity in individual mice, showing a strain-related association between the idiotype and autoanti-TG.
用三种单克隆小鼠自身抗甲状腺球蛋白抗体在兔体内产生抗独特型抗体。在所识别的独特型中，一种是该单克隆抗体所特有的，而另外两种显示出与其他单克隆抗甲状腺球蛋白（TG）独特型共享独特位的证据，特别是IgM独特型在近一半的研究杂交瘤中被发现。两种独特型可在实验性变应性甲状腺炎（EAT）小鼠的血清中检测到，但它们仅占总抗TG的极小比例。尽管在EAT小鼠中其水平较低，但D8独特型可通过注射抗独特型抗体和TG诱导产生，在这种情况下，它在个别小鼠中占抗TG活性的20%，显示出独特型与自身抗TG之间的品系相关关联。
