Cruz-Vidal M, Garcia-Palmieri M R, Costas R, Sorlie P D, Havlik R J
Diabetes Care. 1983 Nov-Dec;6(6):556-61. doi: 10.2337/diacare.6.6.556.
The presence of abnormal blood glucose (ABG) was determined for participants in the Puerto Rico Heart Health Program, a prospective epidemiological study of cardiovascular disease. Subjects were considered to have ABG at baseline if they were receiving treatment for diabetes (diet, oral hypoglycemics, or insulin), or if the blood glucose level was 140 mg/dl or more. Urban-rural comparisons of the prevalence of ABG were made in this cohort of 2585 rural and 6208 urban men aged 45-64 yr. The prevalence of ABG in the urban population was more than double that in the rural. This population has been followed up for coronary heart disease (CHD) over an 8 1/4-yr period. ABG at baseline is significantly associated with CHD death in urban men. When the relationship is controlled for smoking, systolic blood pressure, cholesterol, and relative weight, the relationship remains significant. The association with total CHD is similar. Either by adjusting for diabetes (i.e., when treated diabetes was excluded from analysis) or by entering both blood glucose and diabetes under treatment into the model, blood glucose was no longer statistically significant. This suggests that ABG, rather than blood glucose alone, is the important variable associated with CHD.
在波多黎各心脏健康项目中，对参与者的异常血糖（ABG）情况进行了测定。该项目是一项关于心血管疾病的前瞻性流行病学研究。如果受试者正在接受糖尿病治疗（饮食、口服降糖药或胰岛素治疗），或者血糖水平达到140毫克/分升及以上，则在基线时被视为患有ABG。在这个由2585名45 - 64岁农村男性和6208名城市男性组成的队列中，对ABG患病率进行了城乡比较。城市人群中ABG的患病率是农村人群的两倍多。该人群已被随访8又1/4年以观察冠心病（CHD）情况。基线时的ABG与城市男性的CHD死亡显著相关。在对吸烟、收缩压、胆固醇和相对体重进行控制后，这种关系仍然显著。与总CHD的关联情况类似。要么通过对糖尿病进行调整（即从分析中排除接受治疗的糖尿病患者），要么将血糖和正在接受治疗的糖尿病都纳入模型，此时血糖不再具有统计学显著性。这表明与CHD相关的重要变量是ABG，而非单纯的血糖。
