Schmidt W, Klinga K, Neudeck K, Runnebaum B, Kubli F
Geburtshilfe Frauenheilkd. 1983 Nov;43(11):664-9. doi: 10.1055/s-2008-1036730.
In 83 patients with an ectopic pregnancy the serum levels of HCG and the pregnancy specific beta 1 glycoprotein SP-1 were determined. In addition the serum levels of 25 patients with a nonviable pregnancy and 26 non-pregnant patients were determined. The radio-immunologic beta HCG and SP-1 tests and the enzyme immunologic Sp-1 test were used. The radio-immune assay of beta HCG diagnosed 96% of all cases with an ectopic pregnancy. The enzyme and radio-immunologic SP-1 tests failed to diagnose the ectopic pregnancy in 5 of 83 cases (6%) by the Elisa test and in 3 of 83 cases (4%) by the RIA test. The lower limit of diagnosis of pregnancy was considered to be 1.8 micrograms SP-1/1. The concomitant determination of the beta HCG and the SP-1 level permits the diagnosis of ectopic pregnancy in all cases. The main advantage of the enzyme immunologic determination compared to the radio-immunologic determination is at present the materially shorter time factor of the test and the fact that an isotope laboratory is not necessary.
对83例异位妊娠患者测定了血清人绒毛膜促性腺激素（HCG）水平和妊娠特异性β1糖蛋白（SP-1）水平。此外，还测定了25例胚胎停育患者和26例非妊娠患者的血清水平。采用放射免疫法检测β-HCG和SP-1以及酶免疫法检测SP-1。β-HCG放射免疫测定法诊断出了96%的异位妊娠病例。酶免疫法和放射免疫法检测SP-1时，酶联免疫吸附测定法（Elisa）在83例中有5例（6%）未能诊断出异位妊娠，放射免疫测定法（RIA）在83例中有3例（4%）未能诊断出异位妊娠。妊娠诊断的下限被认为是1.8微克SP-1/升。同时测定β-HCG和SP-1水平可在所有病例中诊断出异位妊娠。与放射免疫测定法相比，酶免疫测定法目前的主要优点是检测时间明显更短，且无需同位素实验室。
