Smith D H, Sinosich M J, Saunders D M
J Reprod Med. 1981 Nov;26(11):555-7.
Levels of pregnancy-specific beta 1 glycoprotein (SP1) and beta-subunit human chorionic gonadotropin (beta-hCG) were measured in the plasma of 22 subjects in early pregnancy following spontaneous or induced ovulation. Minimum baseline levels for pregnancy detection were set at 4 microgram/liter for SP1 an 15 IU/liter for beta-hCG. Using these levels, in some cases SP1 was detectable by day 17 following ovulation and beta-hCG by day 13. All patients were diagnosed as pregnant by day 20 using SP1 and by day 18 using beta-hCG. Both placental proteins had similar doubling times in the plasma. These was no difference between pregnancies following spontaneous and induced ovulation. Until accurate normal ranges can be obtained, there will be problems of interpretation of levels near the limits of the sensitivities of the assay in clinical situations.
在22名自发排卵或诱导排卵后的早孕受试者血浆中，检测了妊娠特异性β1糖蛋白（SP1）和人绒毛膜促性腺激素β亚基（β-hCG）的水平。妊娠检测的最低基线水平设定为SP1为4微克/升，β-hCG为15国际单位/升。根据这些水平，在某些情况下，排卵后第17天可检测到SP1，第13天可检测到β-hCG。所有患者在第20天使用SP1诊断为怀孕，在第18天使用β-hCG诊断为怀孕。两种胎盘蛋白在血浆中的倍增时间相似。自发排卵和诱导排卵后的妊娠之间没有差异。在获得准确的正常范围之前，临床情况下在检测灵敏度极限附近的水平解释会存在问题。
