Taylor B, Finger T E, D'Arcy G, Roper S D
J Comp Neurol. 1983 Dec 1;221(2):145-53. doi: 10.1002/cne.902210203.
The degree of accuracy with which regenerating preganglionic parasympathetic fibers can restore their original connections was examined in the frog, Rana pipiens. The normal motor pool of the vagus nerve was determined by labeling the vagal cardiac branch fibers with horseradish peroxidase (HRP). Cardiac neurons form a relatively compact subgroup within the rostral half of the vagal motor column and represent less than 5% of the total vagal motor pool. Five to 14 weeks after crushing the vagus nerve, HRP labeling revealed that a more extensive population of vagal motor neurons has reinnervated the cardiac branch. The regenerated cardiac motor neuron pool is about twice as numerous as normal but is still centered in the rostral half of the vagal motor column. These experiments show that regeneration of the cardiac branch of the vagus nerve is neither a random process nor one which is completely accurate. Some degree of accuracy is maintained during regeneration following a crush lesion. Neurons nearer the original cardiac motor pool are more likely to reinnervate the cardiac branch than are vagal motor neurons located at some distance from the original cardiac pool.
在牛蛙（Rana pipiens）中，研究了再生的节前副交感神经纤维恢复其原始连接的精确程度。通过用辣根过氧化物酶（HRP）标记迷走神经的心脏分支纤维来确定迷走神经的正常运动神经元池。心脏神经元在迷走运动柱的前半部分形成一个相对紧密的亚群，占迷走运动神经元池总数的不到5%。在迷走神经切断5至14周后，HRP标记显示，更多的迷走运动神经元重新支配了心脏分支。再生的心脏运动神经元池数量约为正常的两倍，但仍集中在迷走运动柱的前半部分。这些实验表明，迷走神经心脏分支的再生既不是一个随机过程，也不是一个完全精确的过程。在挤压损伤后的再生过程中保持了一定程度的精确性。与距离原始心脏运动神经元池较远的迷走运动神经元相比，靠近原始心脏运动神经元池的神经元更有可能重新支配心脏分支。
