Lopez C, Fitzgerald P A, Siegal F P
J Infect Dis. 1983 Dec;148(6):962-6. doi: 10.1093/infdis/148.6.962.
Natural killer cell function, directed against either K562 tumor targets or herpes simplex virus type 1-infected fibroblasts, was often low in patients with acquired immune deficiency syndrome (AIDS) but failed to distinguish these patients from either male homosexual controls or patients with lymphadenopathy. Mononuclear cells from patients with AIDS and opportunistic infections generated diminished levels of interferon-alpha in response to herpes simplex virus type 1-infected fibroblasts. This deficiency discriminated patients with severe opportunistic infections from most individuals with either generalized lymphadenopathy or Kaposi's sarcoma only and from male homosexual control subjects. The deficiency in interferon-alpha generation may be the consequence of the opportunistic infections that these individuals have contracted or may be a direct manifestation of AIDS itself.
针对K562肿瘤靶标或1型单纯疱疹病毒感染的成纤维细胞的自然杀伤细胞功能，在获得性免疫缺陷综合征（AIDS）患者中通常较低，但无法将这些患者与男性同性恋对照者或淋巴结病患者区分开来。患有AIDS和机会性感染的患者的单核细胞对1型单纯疱疹病毒感染的成纤维细胞产生的α干扰素水平降低。这种缺陷仅将患有严重机会性感染的患者与大多数患有全身性淋巴结病或卡波西肉瘤的个体以及男性同性恋对照者区分开来。α干扰素产生的缺陷可能是这些个体所感染的机会性感染的结果，也可能是AIDS本身的直接表现。
