Vidrnová M, Nouza K
Neoplasma. 1983;30(5):527-32.
The nature of the development of tumor grafts of Sarcoma I in allogeneic mice is determined by the immunogenicity of membrane markers of tumor cells coded by the major H-2 system. Minor (non-H-2) systems fail to assert themselves in tumor transplantation. The role of various subregions of the H-2 system may already be followed in normal Sa I recipients: a more striking differentiation is achieved in hosts treated with xenogeneic antilymphocyte serum. Those presenting the strongest barrier were specificities coded by the entire region of the H-2 complex. Of the subregions of the H-2 system studied here, H-2K meant a stronger barrier to tumor growth than the H-2D region. When the tumor antigenic specificities of both H-2K and H-2D regions were extended to include also those of the H-21 regions, tumor growths were for the most part restricted; on the other hand, the inclusion in tumor antigen specificities coded by H-2KAB of the JE region specificities brought about a moderate stimulation in tumor growth. This differences in the fate of tumor allograft may be due to a quantitatively or qualitatively different development of the host's immune response against various tumor antigen specificities coded by subregions of the H-2 system or to a varying ability of the tumor grow across different barriers of the H-2 system.
I型肉瘤在同种异体小鼠体内肿瘤移植物的发展性质，由主要H-2系统编码的肿瘤细胞膜标记物的免疫原性决定。次要（非H-2）系统在肿瘤移植中不起作用。在正常的I型肉瘤受体中，或许已能看出H-2系统各亚区的作用：在用异种抗淋巴细胞血清处理的宿主中，能实现更显著的分化。构成最强屏障的是由H-2复合体整个区域编码的特异性。在此研究的H-2系统亚区中，H-2K对肿瘤生长的屏障作用比H-2D区域更强。当H-2K和H-2D区域的肿瘤抗原特异性扩展到也包括H-2I区域的那些特异性时，肿瘤生长大多受到限制；另一方面，将JE区域特异性纳入由H-2KAB编码的肿瘤抗原特异性中，会导致肿瘤生长受到适度刺激。肿瘤同种异体移植物命运的这种差异，可能是由于宿主针对由H-2系统亚区编码的各种肿瘤抗原特异性的免疫反应在数量或质量上发展不同，或者是由于肿瘤跨越H-2系统不同屏障生长的能力不同。
