Lindholm T S
J Trauma. 1978 May;18(5):336-40. doi: 10.1097/00005373-197805000-00007.
Adult male rats maintained on a low calcium intake during 6 weeks prefracture developed osteoporotic changes of the tibia fracture during a healing period of another 6 weeks. Treatment based on combined use of daily peroral doses of 1alpha- hydroxycholecalciferol and an optimal calcium intake reversed the osteoporotic changes in the fractured tibia after only 2 weeks, and the act of reversion became still more pronounced after 4-6 weeks. 1alpha-hydroxycholecalciferol treatment is recorded, when supported by an optimal calcium intake, to positively influence the levels of serum calcium, dry weight, and total ash content as specific weight and cortical thickness of the fractured tibia, following experimental fractures.
成年雄性大鼠在骨折前6周维持低钙摄入，在接下来6周的愈合期出现了胫骨骨折的骨质疏松变化。基于每日口服1α-羟基胆钙化醇和最佳钙摄入量联合使用的治疗在仅2周后就逆转了骨折胫骨的骨质疏松变化，并且在4 - 6周后逆转作用变得更加明显。记录显示，在最佳钙摄入量的支持下，1α-羟基胆钙化醇治疗对实验性骨折后血清钙水平、干重、骨折胫骨的总灰分含量（作为比重）和皮质厚度有积极影响。
