Smith R N, Yaw P B, Glover J L
J Trauma. 1978 May;18(5):341-4. doi: 10.1097/00005373-197805000-00008.
Contamination of blood by bowel contents has been generally assumed as an absolute contraindication to autotransfusion. Since abdominal trauma is frequently accompanied by bowel injury and massive blood loss, a potential major use for autotransfusion has thus been precluded. To test this presumption, autologous blood grossly contaminated with feces was incubated in the peritoneal cavity and then autotransfused in dogs. The animals were hemorrhaged 20, 30, or 40% of their estimated blood volume, producing mild to severe hypovolemic shock. Reinfusion of contaminated blood had little effect on survival with 20 or 30% hemorrhage, but contamination markedly decreased survival with 40% hemorrhage:90% survived without contamination while only 30% survived with contamination. The use of antibiotics in a similar group of dogs subjected to 40% hemorrhage essentially eliminated the risk of autotransfusion: 90% of these dogs survived autotransfusion of contaminated blood.
肠内容物对血液的污染通常被视为自体输血的绝对禁忌证。由于腹部创伤常伴有肠损伤和大量失血，因此自体输血的一个潜在主要用途被排除在外。为了验证这一假设，将严重被粪便污染的自体血在腹腔中孵育，然后输给犬类。给动物放血，放血量为其估计血容量的20%、30%或40%，造成轻度至重度低血容量性休克。回输污染血液对20%或30%失血量的动物的存活率影响不大，但对于40%失血量的动物，污染显著降低了存活率：无污染时90%存活，而污染时只有30%存活。在一组失血量为40%的类似犬类中使用抗生素基本消除了自体输血的风险：这些犬类中90%在回输污染血液后存活。
