Mitrokhina L A, Lebenzon S S
Zh Nevropatol Psikhiatr Im S S Korsakova. 1983;83(10):1478-80.
Fourteen children aged 4 to 12 years suffering from subacute sclerosing panencephalitis (SSPE) were observed. Prior to the treatment initiation, cellular immunity was studied in seven children who had been hospitalized over the last three years. An analysis of the findings showed that the patients' peripheral blood displayed the deficit of the total number of T lymphocytes (1.12.10(9)/1 +/- 0.06.10(9)/1) as compared with this value in age-matched healthy children (2.12.10(9)/1 +/- 0.04.10(9)/1) and also the deficit of the subpopulations of "active" and T lymphocyte suppressors; 60.0 +/- 4.1% of the total number of T lymphocytes proved to be poorly receptive compared to 30.6 +/- 2.6% in healthy children. The count of D lymphocytes remained practically unaltered whereas the content of B lymphocytes, macro- and microphages in the peripheral blood exceeded considerably the normal values for a given age. The evidence obtained suggests that patients with SSPE have sufficient indications for directed pharmacological immunocorrection.
观察了14名4至12岁患有亚急性硬化性全脑炎（SSPE）的儿童。在开始治疗前，对过去三年住院的7名儿童进行了细胞免疫研究。对研究结果的分析表明，与年龄匹配的健康儿童（2.12×10⁹/升±0.04×10⁹/升）相比，患者外周血中T淋巴细胞总数减少（1.12×10⁹/升±0.06×10⁹/升），“活跃”T淋巴细胞亚群和T淋巴细胞抑制因子也减少；T淋巴细胞总数的60.0%±4.1%反应性较差，而健康儿童为30.6%±2.6%。D淋巴细胞计数基本未变，而外周血中B淋巴细胞、巨噬细胞和微巨噬细胞的含量大大超过了给定年龄的正常值。所获得的证据表明，SSPE患者有足够的指征进行定向药理免疫纠正。
