Rosenthal M, Steinmann A
Dtsch Med Wochenschr. 1978 Mar 10;103(10):409-12. doi: 10.1055/s-0028-1104449.
The total lymphocyte count and the different lymphocyte subpopulations were determined in peripheral blood of healthy probands aged 20 to 90 years. With increasing age there is a slow decrease of the total lymphocyte count and of the subpopulations. This was most evident in the decrease in thymus dependent lymphocytes (T cells) which carry cellular immunity. These results support the assumption that with increasing age cellular immunity is clearly reduced and may possibly be associated with an increased incidence of neoplasia, infection, and auto-immune disease. Estimations of lymphocytes and their subpopulations in peripheral blood allow some conclusions as to the immunological resistance which is largely dependent on these cells. Estimation of the number of circulating lymphocytes in relation to age is thus indispensable for the assessment of the immunological reactivity of patients.
对年龄在20至90岁的健康受试者外周血中的淋巴细胞总数及不同淋巴细胞亚群进行了测定。随着年龄的增长，淋巴细胞总数及亚群数量会缓慢下降。这在具有细胞免疫功能的胸腺依赖性淋巴细胞（T细胞）的减少中最为明显。这些结果支持了这样一种假设，即随着年龄的增长，细胞免疫明显降低，并且可能与肿瘤、感染及自身免疫性疾病的发病率增加有关。对外周血中淋巴细胞及其亚群的评估有助于得出一些关于免疫抵抗力的结论，而免疫抵抗力在很大程度上取决于这些细胞。因此，评估与年龄相关的循环淋巴细胞数量对于评估患者的免疫反应性是必不可少的。
