Dalaker K, Prydz H
Br J Haematol. 1984 Feb;56(2):233-41. doi: 10.1111/j.1365-2141.1984.tb03951.x.
The hypercoagulable state in pregnancy is partly caused by the increased activity of factor VII in plasma. We demonstrate here that this activity is reduced to levels similar to those in plasma from non-pregnant women by highly purified phospholipase C from Bacillus cereus, i.e. the activity increase is due to a circulating complex of factor VII and a phospholipase C-sensitive compound. Phospholipase C had no effect on the levels of factor II and X in blood from pregnant women. This novel form of activated factor VII is not inhibited by an antiserum to the protein component of thromboplastin (apoprotein III). By gel filtration of plasma from pregnant women on Sephadex G-100 the phospholipase C-sensitive complex was partly separated from non-phospholipase sensitive factor VII also present in the same plasma.
孕期的高凝状态部分是由血浆中因子VII活性增加所致。我们在此证明，蜡样芽孢杆菌的高纯度磷脂酶C可将该活性降低至与非孕妇血浆中的水平相似，即活性增加是由于因子VII与一种对磷脂酶C敏感的化合物形成了循环复合物。磷脂酶C对孕妇血液中因子II和X的水平没有影响。这种新型的活化因子VII不受针对凝血活酶蛋白成分（脱辅基蛋白III）的抗血清抑制。通过在Sephadex G - 100上对孕妇血浆进行凝胶过滤，可将对磷脂酶C敏感的复合物与同一血浆中存在的对磷脂酶不敏感的因子VII部分分离。
