Laschinger C, Shepherd F A, Naylor D H
Can Med Assoc J. 1984 Jan 15;130(2):141-4.
During a 6-year period (1977 to 1982) blood samples from 152 Canadian patients were referred to the national reference laboratory of the Canadian Red Cross Society because the referring hospitals had not been able to determine the cause of the patients' severe nonhemolytic transfusion reactions. Twenty-one patients were found to be IgA deficient, and 12 of them had strong class-specific anti-IgA antibodies, which were presumed to have been responsible for the reactions. The spectrum of symptoms that accompanied these violent reactions was documented for 10 of the patients. As a probable minimum, the incidence of anti-IgA-mediated reactions averaged 1.3 per million units of blood or blood products transfused during this period.
在1977年至1982年的6年期间，152名加拿大患者的血样被送往加拿大红十字会国家参考实验室，因为转诊医院无法确定患者严重非溶血性输血反应的原因。发现21名患者存在IgA缺陷，其中12名有强烈的类特异性抗IgA抗体，推测这些抗体是导致反应的原因。记录了10名患者发生这些剧烈反应时伴随的症状谱。在此期间，抗IgA介导反应的发生率可能至少平均为每输注100万单位血液或血液制品中有1.3例。
