Koskinen S, Tölö H, Hirvonen M, Koistinen J
Finnish Red Cross Blood Transfusion Service, Helsinki.
J Clin Immunol. 1995 Jul;15(4):194-8. doi: 10.1007/BF01541089.
A follow-up study of anti-IgA antibodies in 159 healthy blood donors with severe deficiency of serum IgA (< 0.05 mg/L) and in 45 donors with decreased serum IgA levels (0.05-799 mg/L), identified in 1971-1980, was carried out. Initially anti-IgA antibodies were determined by a hemagglutination (HA) method and two reexaminations were done in 1990-1992 by an enzyme immunoassay. The median follow-up period was 19 years, during which anti-IgA level was changed considerably in only four persons, increased in two, and high level antibodies (> 1/1000 by HA) appeared in two. In reexaminations anti-IgA antibodies were found in 30 (19%) subjects with severe IgA deficiency and the antibody levels remained relatively constant in those who had high and medium antibody levels. Anti-IgA antibodies were not found in subjects with decreased, but detectable serum IgA. Thus it seems that only those healthy adults who have severe IgA deficiency develop anti-IgA antibodies and their anti-IgA levels remain fairly constant. Of the 159 subjects with severe IgA deficiency, 66 had a history of IgA exposure, but no correlation to anti-IgA development was noted.
对1971年至1980年间确定的159名血清IgA严重缺乏（<0.05mg/L）的健康献血者和45名血清IgA水平降低（0.05 - 799mg/L）的献血者进行了抗IgA抗体的随访研究。最初通过血凝（HA）法测定抗IgA抗体，并在1990年至1992年通过酶免疫测定法进行了两次复查。中位随访期为19年，在此期间，只有4人的抗IgA水平有显著变化，2人升高，2人出现高水平抗体（HA法>1/1000）。在复查中，30名（19%）严重IgA缺乏的受试者中发现了抗IgA抗体，高抗体水平和中抗体水平的受试者抗体水平保持相对稳定。血清IgA水平降低但可检测到的受试者未发现抗IgA抗体。因此，似乎只有那些严重IgA缺乏的健康成年人会产生抗IgA抗体，且其抗IgA水平保持相当稳定。在159名严重IgA缺乏的受试者中，66人有IgA接触史，但未发现与抗IgA产生相关。
