α2高分子量半胱氨酸蛋白酶抑制剂：HMrα2-CPI。通过动力学研究探究其作为人肝脏组织蛋白酶H的抑制剂的特性。
Alpha 2 high molecular mass cysteine proteinase inhibitor: HMr alpha 2-CPI. An inhibitor of human liver cathepsin H as probed by kinetic study.
作者信息
Pagano M, Engler R
出版信息
FEBS Lett. 1984 Jan 23;166(1):62-6. doi: 10.1016/0014-5793(84)80045-9.
PMID:6607180
Abstract
HMr alpha 2CPI was found to be an inhibitor of human liver cathepsin H by the measurement of the dissociation constant (Ki), the association rate constant (k1) and the dissociation rate constant (k-1) between the enzyme and the inhibitor. These data suggest that this protein-proteinase inhibitor can play a physiological role in the regulation of free cathepsin H.
摘要
通过测量酶与抑制剂之间的解离常数（Ki）、结合速率常数（k1）和解离速率常数（k-1），发现HMrα2CPI是人类肝脏组织蛋白酶H的一种抑制剂。这些数据表明，这种蛋白质-蛋白酶抑制剂在游离组织蛋白酶H的调节中可能发挥生理作用。
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