急性前葡萄膜炎的遗传标记物。

Genetic markers for acute anterior uveitis.

作者信息

LeClercq S A, Percy J S, Russell A S

出版信息

J Rheumatol. 1983 Dec;10(6):998-1000.

Abstract

One hundred and sixty-nine patients, 82 with acute anterior uveitis (AAU) only, 48 with AAU and ankylosing spondylitis (AS), and 39 with AS only were studied. The HLA antigen A2 was present in 44/82 AAU only, 31/48 AAU + AS, and 23/39 AS only. Where haplotype analysis was possible by virtue of family studies, A2 B27 was present in 7/16 AAU only, 9/15 AAU and AS and 14/29 AS only. These figures do not differ significantly from the expected values of control populations. Alpha-1-antitrypsin (alpha-1-AT) phenotypes were obtained on 30/82 AAU only, 29/48 AAU + AS, and 27/39 AS only patients. The MZ phenotype appeared in 8/86 patients tested; 4/30 with AAU only and 4/29 AAU + AS patients. This is higher than the expected value for control populations. Therefore, MZ alpha-1-AT phenotype but not HLA-A2 appears increased in patients with AAU.

摘要

对169例患者进行了研究，其中82例仅患有急性前葡萄膜炎（AAU），48例患有AAU和强直性脊柱炎（AS），39例仅患有AS。HLA抗原A2在仅患有AAU的82例患者中有44例出现，在AAU + AS的48例患者中有31例出现，在仅患有AS的39例患者中有23例出现。通过家系研究进行单倍型分析时，A2 B27在仅患有AAU的16例患者中有7例出现，在AAU和AS患者中有9例出现，在仅患有AS的29例患者中有14例出现。这些数字与对照人群的预期值没有显著差异。仅对82例AAU患者中的30例、48例AAU + AS患者中的29例和39例AS患者中的27例进行了α-1-抗胰蛋白酶（α-1-AT）表型分析。在86例接受检测的患者中出现了MZ表型；仅患有AAU的30例患者中有4例，AAU + AS患者中有4例。这高于对照人群的预期值。因此，AAU患者中MZ α-1-AT表型增加，而HLA-A2未增加。