苗勒管退化过程中的磷酸化事件。
Phosphorylation events during Müllerian duct regression.
作者信息
Hutson J M, Fallat M E, Kamagata S, Donahoe P K, Budzik G P
出版信息
Science. 1984 Feb 10;223(4636):586-9. doi: 10.1126/science.6607531.
Regression of the fetal rat Müllerian duct in vitro was stimulated by sodium fluoride in the absence of Müllerian inhibiting substance. The action of Müllerian inhibiting substance was inhibited by sodium vanadate, adenosine 5'-triphosphate, and several related nucleotides in the presence of manganese ions. Epidermal growth factor specifically inhibited the substance, but only with manganese ions present. Insulin, platelet-derived growth factor, and nerve growth factor had no effect. These results suggest that dephosphorylation of membrane proteins mediates the action of Müllerian inhibiting substance.
在没有苗勒管抑制物质的情况下，氟化钠可刺激体外培养的胎鼠苗勒管退化。在锰离子存在的情况下，钒酸钠、腺苷5'-三磷酸及几种相关核苷酸可抑制苗勒管抑制物质的作用。表皮生长因子可特异性抑制该物质，但仅在有锰离子存在时有效。胰岛素、血小板衍生生长因子和神经生长因子则无作用。这些结果表明，膜蛋白的去磷酸化介导了苗勒管抑制物质的作用。
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