[Antagonistic actions of testosterone and the anti-mullerian hormone on the mullerian duct of the chick embryo in culture in vitro].

When cultured in combination with testes of the same stage, müllerian ducts from the 7-7 1/2-day-old chick embryo underwent regression, which was nearly complete in the male and less pronounced in the female after a 4-5-day culture period. When a crystal of testosterone was added in the system, the müllerian ducts were maintained in the male, whereas they were even stimulated in the female. Testosterone therefore antagonizes the suppressive action of the anti-müllerian hormone. The exact nature of the interaction of the two hormones at the cellular and molecular level should be the object of further studies.