Baur X, Wiessmann K J, Wüthrich B
Dtsch Med Wochenschr. 1984 Feb 17;109(7):257-60. doi: 10.1055/s-2008-1069177.
Pancreatic extracts had caused respiratory disease in five patients. Four of them were not atopic. In four cases alpha-amylase and in two cases trypsin could be identified as causative allergen using RAST and RAST-inhibition. In addition, demonstration of immunologic cross-reactivity between porcine and bovine pancreatin was possible. This most likely can be attributed to the structurally closely related enzymes alpha-amylase and trypsin occurring in both animal species.
胰腺提取物已导致5名患者出现呼吸系统疾病。其中4人并非特应性体质。在4例病例中，通过放射变应原吸附试验（RAST）和RAST抑制试验可确定α-淀粉酶为致病过敏原，在2例病例中可确定胰蛋白酶为致病过敏原。此外，还证实了猪胰酶和牛胰酶之间存在免疫交叉反应性。这很可能归因于两种动物体内结构密切相关的酶α-淀粉酶和胰蛋白酶的存在。
