Tateno H, Mikamo K
Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Feb;45(2):139-49. doi: 10.1080/09553008414550161.
The process of ovarian development in neonatal Chinese hamsters aged between 0 and 16 days was studied histologically and quantitatively in both a non-irradiated group and an irradiated group. In the latter, ovaries were exposed to a single dose of 1 Gy X-rays on days 0, 2, 4, 6, 8, 10, 12 and 14 after birth. All oocytes on day 0 were at pachytene, and nearly all of them seemed to develop to dictyate by day 10. A quantitative analysis of age-dependent changes in the distribution of oocytes showed that a marked spontaneous degeneration of oocytes took place twice, i.e. during pachytene (day 0 to day 4) and dictyate (day 12 to day 14). Oocytes of this species were found to be very radioresistant at pachytene, but to become sharply sensitive during the phases between diplotene and early dictyate, suffering an almost complete oocyte-killing after 1 Gy. However, they recovered radioresistance after the onset of the resting stage. The changing aspects of radiosensitivity in the Chinese hamster were shown to be far more marked than in the mouse and the rat, which have been observed by previous investigators.
对0至16日龄新生中国仓鼠的卵巢发育过程进行了组织学和定量研究，分为未照射组和照射组。在后一组中，在出生后的第0、2、4、6、8、10、12和14天，卵巢接受单次1 Gy的X射线照射。出生第0天所有卵母细胞处于粗线期，到第10天几乎所有卵母细胞似乎都发育为双线期。对卵母细胞分布的年龄依赖性变化进行的定量分析表明，卵母细胞明显的自发退化发生了两次，即粗线期（第0天至第4天）和双线期（第12天至第14天）。发现该物种的卵母细胞在粗线期对辐射具有很强的抗性，但在双线期和早期双线期之间的阶段变得非常敏感，在1 Gy照射后几乎所有卵母细胞都死亡。然而，在静止期开始后它们恢复了辐射抗性。结果表明，中国仓鼠辐射敏感性的变化比先前研究者观察到的小鼠和大鼠更为明显。
