Asikainen S, Sandholm L, Sandman S, Ainamo J
J Clin Periodontol. 1984 Feb;11(2):87-94. doi: 10.1111/j.1600-051x.1984.tb00836.x.
In a previous paper a slight increase in gingival bleeding tendency was reported after the use of chlorhexidine rinses in dental students with clinically healthy gingivae. For further clarification of this finding the study was repeated using a split mouth approach. 30 dental students brushed the teeth in either the left or the right side of their mouth twice daily during a 7-day period. After each brushing, they rinsed for 1 min with 10 ml of a 0.2% chlorhexidine digluconate solution. Both the Plaque Index (P1I) scores and the bleeding tendency after massage of the gingival margin were low at the initial examination. The low P1I scores at baseline were further reduced on both sides of the jaws. On the side which was only rinsed the P1I scores were higher than on the side of combined mechanical and chemical cleaning. The gingival bleeding tendency was found to decrease on the brushed side and to increase on the side which was only rinsed. An increased bleeding tendency was most often observed in those individuals whose gingivae were the healthiest at baseline. A SEM analysis of the 2 sides of the dentition indicated that bleeding after chlorhexidine rinses may be associated with irritation from debris which, after the 7-day period of no mechanical oral hygiene measures, seemed to obliterate the gingival sulcus.
在之前的一篇论文中报道,在临床牙龈健康的牙科学生中使用洗必泰漱口液后,牙龈出血倾向略有增加。为了进一步阐明这一发现,采用了双侧对照的方法重复进行该研究。30名牙科学生在7天内每天两次刷牙,每次刷口腔左侧或右侧。每次刷牙后,他们用10毫升0.2%葡萄糖酸洗必泰溶液漱口1分钟。在初始检查时,菌斑指数(PI)得分和牙龈边缘按摩后的出血倾向均较低。基线时较低的PI得分在两侧颌骨上进一步降低。仅进行漱口的一侧PI得分高于机械清洁和化学清洁相结合的一侧。发现刷牙侧的牙龈出血倾向降低,而仅进行漱口的一侧出血倾向增加。出血倾向增加最常出现在基线时牙龈最健康的个体中。对牙列两侧的扫描电镜分析表明,洗必泰漱口后的出血可能与碎屑刺激有关,在7天没有机械口腔卫生措施后,这些碎屑似乎堵塞了牙龈沟。