大脑毒蕈碱型乙酰胆碱受体的外部成像
External imaging of cerebral muscarinic acetylcholine receptors.
作者信息
Eckelman W C, Reba R C, Rzeszotarski W J, Gibson R E, Hill T, Holman B L, Budinger T, Conklin J J, Eng R, Grissom M P
出版信息
Science. 1984 Jan 20;223(4633):291-3. doi: 10.1126/science.6608148.
A radioiodinated ligand that binds to muscarinic acetylcholine receptors was shown to distribute in the brain by a receptor-mediated process. With single-photon-emission imaging techniques, radioactivity was detected in the cerebrum but not in the cerebellum, whereas with a flow-limited radiotracer, radioactivity was detected in cerebrum and cerebellum. Single-photon-emission computed tomography showed good definition of the caudate putamen and cortex in man.
一种与毒蕈碱型乙酰胆碱受体结合的放射性碘化配体经显示是通过受体介导过程在大脑中分布的。利用单光子发射成像技术，在大脑中检测到放射性，但在小脑中未检测到，而对于一种流量受限的放射性示踪剂，在大脑和小脑中均检测到放射性。单光子发射计算机断层扫描显示了人体尾状壳核和皮质的良好清晰度。
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